What Not to Mix with Hyaluronic Acid: A Guide to Safe Skincare Combinations

November 13, 2024
By ZQ-II®


Hyaluronic acid (HA) is generally a versatile and friendly ingredient that pairs well with most other skincare ingredients. However, there are some ingredients that need to be used with caution when using  to ensure maximum benefits and prevent skin irritation. Here is a guide on what ingredients not to mix with HA or how to handle certain combinations:

1. Highly acidic ingredients (like some forms of vitamin C)

Why: L-ascorbic acid is a potent form of vitamin C with a very low pH, which may not be suitable for use in the same step as HA, especially if you have sensitive skin.

How to use safely: You can separate vitamin C and HA or use them at different times of the day. For example, use vitamin C in the morning to benefit from its antioxidant properties and ZQ-II HA Serum in the evening to moisturize.

2. Exfoliating acids (AHA and BHA)

Why: While it is safe to layer AHAs (like glycolic acid) or BHAs (like salicylic acid) with HA, using too many active ingredients at the same time can cause irritation, especially for sensitive skin.

How to use it safely: Use ZQ-II HA Serum after using an exfoliating acid to soothe and moisturize your skin. Or, if you notice skin sensitivity, alternate between using it on different days.

3. Retinoids and retinols

Why: Hyaluronic acid itself is generally safe to use with retinoids and retinols. However, using retinoids with strong active ingredients in the same step can sometimes cause irritation.

How to use it safely: After using a retinoid or retinol, use ZQ-II HA Serum is possible. This layering helps prevent skin dryness and irritation. If you have extremely sensitive skin, try using ZQ-II HA Serum in the morning and retinoids at night.


4. Products with high alcohol content

Why: Products with high alcohol content can dry out your skin and counteract the moisturizing effects of hyaluronic acid.

How to use it safely: If you use products with alcohol, apply ZQ-II HA Serum after use to help hydrate your skin. For better results, avoid skin care products with high alcohol content when possible.

5. Sodium PCA and Glycerin in Very Humid Environments

Why: In very humid environments, combining too many humectants (like hyaluronic acid, glycerin, and sodium PCA) can draw excess moisture into the skin, which some people find uncomfortable.

Safe Use: Use one moisturizer like ZQ-II HA Serum at a time, or use less in high humidity conditions.

General Tips for Using Hyaluronic Acid with Other Ingredients:

Apply ZQ-II HA Serum to damp skin: This helps the hyaluronic acid absorb moisture from the air and promotes hydration.

Use a Moisturizer Over ZQ-II HA Serum: Use a good moisturizer to lock in the moisture provided by hyaluronic acid for maximum hydration.

For the most part, hyaluronic acid is very compatible with other ingredients, but paying attention to your skin's reaction when using ZQ-II HA Serum can help you get the best results!



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